EFFECTS OF DIURNAL HORMONAL CHANGES ON MATRIX METABOLISM
$0M01FY2002RRNIH
Weill Medical College Of Cornell Univ, New York NY
Investigators
Linked publications & trials
Paper 22292110Paper 20977343Paper 19906219Paper 19391080Paper 19017985Paper 18097152Paper 17316097Paper 17079285Paper 16763388Paper 16339698Paper 15526720Paper 15270860Paper 14962217Paper 14703595Paper 14625263Paper 14581545Paper 12654942Paper 12525204Paper 12468338Paper 12442030Paper 12393516Paper 12027270Paper 11967296Paper 11880731Paper 11821496Paper 11781358Paper 11605171Paper 11391167Paper 11335777Paper 11335753Paper 11170984Paper 11135346Paper 11085758Paper 11075607Paper 10912545Paper 10880061Paper 10807191Paper 10783035
Abstract
In six growth hormone-sufficient patients of a pilot study, we have shown synchronicity between nocturnal fluctuations of growth hormone (GH) and PICP, a serum marker of biosynthesis of type I procollagen. We also discovered down-regulation of PICP coincident with the AM rise in cortisol (F). We now intend to further clarify the modulation of PICP by 1. The physiological fluctuation of endogenous GH and F; 2) The administration of exogenous GH; and by(3) The inhibition of endogenous F. We will include profibrotic hormone aldosterone, which also shows diurnal variablility in both GH-deficient and GH sufficient patients.
View original record on NIH RePORTER →