INTRAVENOUS TGF1 INFUSION IN HEAD INJURY

$0M01FY2002RRNIH

University Of Kentucky, Lexington KY

Investigators

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Abstract

Test the hypothesis that intravenous (IV) IGF-1 administration enhances brain parenchymal reorganization and thereby improves neurologic outcome. Test the hypothesis that IV IGF-1 administration decreases hyperglycemia, decreases brain lactic acidosis, and prevents secondary brain injury from acidosis. Test the hypothesis that IV IGF-1 administration prevents the catabolic sequelae to injury, preserves normal blood amino acid ratios, decreases excitotoxic amino acids presented to the brain, and thereby improves recovery.

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