THERAPY OF HIV RELATED TUBERCULOSIS USING RIFABUTIN

$0M01FY2002RRNIH

University Of Texas Hlth Sci Ctr San Ant, San Antonio TX

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Abstract

This CDC-sponsored, multi-center study will determine the effectiveness of rifabutin as a substitute for rifampin in the treatment of tuberculosis in HIV+ patients. Rifampin, which is generally successful against tuberculosis, has significant interaction with the hepatically metabolized drugs required to stabilize HIV resulting in 40-90% decreases in serum concentrations of the protease inhibitors. The study drug is also a rifamycin antibiotic but does not appear to reduce protease inhibitor serum concentrations to as great a degree.

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