Elucidating Molecular Mechanisms of Gating Regulation and Subunit Modulation of N-glycosylation on Ion Channels by Using Molecular Dynamics Simulations

$183,125P20FY2024GMNIH

University Of Mississippi, University MS

Investigators

James Alfred Stewartcontact Samir A Ross

Linked publications & trials

Paper 39483353 Paper 39386581 Paper 39314455 Paper 39286500 Paper 39284455 Paper 39257759 Paper 39229059 Paper 39118622 Paper 38998918 Paper 38786623 Paper 38739531 Paper 38642280 Paper 38606727 Paper 38583808 Paper 38572510 Paper 38557311 Paper 38457653 Paper 38410026 Paper 38400013 Paper 38398586 Paper 38393052 Paper 38269098 Paper 38237114 Paper 38204762 Paper 38174900 Paper 37921445 Paper 37822920 Paper 37788674 Paper 37687244 Paper 37601375 Paper 37546180 Paper 37329611 Paper 37306476 Paper 37233458 Paper 37167245 Paper 37112839 Paper 36963552 Paper 36959228 Paper 36945379 Paper 36824802 Paper 36512753 Paper 36512328 Paper 36479973 Paper 36454453 Paper 36436858 Paper 36374992 Paper 36246230 Paper 36200072 Paper 36136750 Paper 36125638 Paper 35854001 Paper 35820157 Paper 35788318 Paper 35551273 Paper 35416212 Paper 35337800 Paper 35248671 Paper 35237922 Paper 35108013 Paper 34878720 Paper 34674390 Paper 34537241 Paper 34451811 Paper 34385565 Paper 34202719 Paper 34124917 Paper 33881849 Paper 33864843 Paper 33560821 Paper 33259925 Paper 33173010 Paper 33066214 Paper 33049007 Paper 32902282

Abstract

Individuals suffering from cognitive impairment, impaired Sleep, and muscle loss in advanced age are faced with the loss of independence, decreased healthspan, and increased financial burden. Understanding the glycomolecular mechanisms that instigate these impairments is of critical importance. This proposal examines how the accumulation of advanced glycation end products (AGEs) and their receptor (RAGE) contributes to the onset of these behavioral impairments throughout an animals lifespan to negatively impact healthspan.

View original record on NIH RePORTER →