PHYSIOLOGICAL AND GENETIC ELUCIDATION OF GOUTY DIATHESIS

$321,374M01FY2002RRNIH

University Of Texas Sw Med Ctr/Dallas, Dallas TX

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Abstract

Gouty diathesis is a stone-forming entity that is associated with primary gout. The goal of this project is to define physiological markers for gouty diathesis which could be utilized in tracking afflicted family members in the molecular biological elucidation of this entity. The hypothesis to be tested is that patients with gouty diathesis compared to normal subjects, will show a lower urinary NH4+ and pH at comparable acid load/alkali deficit.

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