CONTINUOUS TAXOL AND RADIATION FOR ADVANCED HEAD/NECK SQUAMOUS CELL CARCINOMA

$321,374M01FY2002RRNIH

University Of Texas Sw Med Ctr/Dallas, Dallas TX

Investigators

Linked publications & trials

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Abstract

Standard therapy for locally advanced head & neck squamous cell carcinoma involves combined radiation therapy and surgery for resectable cases, & radiation therapy alone for those deemed unresectable. Even with maximal tolerated doses of radiation, locoregional failure is the main tumor control issue, but at least 10-20% also develop clinically apparent distant metastases. Taxol has shown significant activity as a single agent in both untreated and previously treated head & neck cancer. Also, synergy has been demonstrated between taxol and radia-

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