DEXTROMETHORPHAN CYP3A PROBE &GRAPEFRUIT JUICE ON CYCLO

$0M01FY2002RRNIH

University Of Iowa, Iowa City IA

Investigators

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Abstract

This study is evaluating the relationship of the metabolic ratio of dextromethorphan/3-methoxymorphinan in 24 hour urine with cyclosporine pharmacokinetics and differentiating the metabolism of cyclosporine in the liver from that in the intestinal wall by using grapefruit juice in healthy African American subjects.

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