Evaluation of multiple test agents for functional cardiovascular changes in rats

Battelle Memorial Institu, Columbus OH

Investigators

Abstract

This project supports the Division of Translational Toxicology cardiovascular Health Effect Innovation program by testing a suite of 9-10 chemicals in rats with implanted telemetry devices. Rats will be dosed in a dose-escalation design to evaluate functional changes related to cardiovascular health (e.g. blood pressure, heart rate, respiratory rate).