L 753099 IN POSTMENOPAUSAL WOMEN W/ URINARY INCONTINENCE

$0M01FY2002RRNIH

University Of Pittsburgh At Pittsburgh, Pittsburgh PA

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Abstract

This is a double-blind, randomized, placebo-and-active-comparator controlled multicenter study in which approximately 510 patients with predominately urge urinary incontinence will receive l-753099 at doses of 2mg, 1mg, and 0.5mg in the A.M., 2mg in the P.M. Tolterodine 2mg B.I.D. or placebo for 12 weeks. l-753099 is an antimuscarinic agent with selectivity for human M3 over M2. M2-mediated side effects of other muscarinic agents may be reduced through the use of l-753099 while efficacy of the drug for affecting urinary incontinence is not changed.

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