GGrantIndex
← Search

Pathogenesis and Chemotherapy of Human Virus Infections

$426,854ZIAFY2023AINIH

National Institute Of Allergy And Infectious Diseases

Investigators

Jeffrey Cohencontact

Linked publications, trials & patents

Paper 37011643Paper 36759741Paper 34655400Paper 34171765Paper 33661412Paper 33095855Paper 32364538Paper 32213613Paper 32117278Paper 31714901Paper 30470981Paper 30274169Paper 30170123Paper 30111570Paper 29921983Paper 29718378Paper 29712633Paper 29693655Paper 29599765Paper 29375553Paper 29046461Paper 28630417Paper 28581445Paper 27025823Paper 26559845Paper 26482341Paper 26424649Paper 26147640Paper 26018166Paper 26018161Paper 25798530Paper 24890818Paper 24623429Paper 24312567Paper 23680202Paper 23300908Paper 23067008Paper 22262788Paper 21960712Paper 21943244Paper 21749586Paper 20823288Paper 20419813Paper 19889786Paper 19269661Paper 19200567Paper 18678906Paper 17459924Paper 16254342Paper 11483762Paper 11118375Paper 10864685Paper 10844903Paper 10635049

Abstract

Epstein Barr virus (EBV) is associated with 200,000 cases of cancer each year worldwide and is the cause of infectious mononucleosis. The virus is associated with nasopharyngeal carcinoma, gastric carcinoma, Burkitt lymphoma, and Hodgkin disease. The virus causes lymphomas in some persons who have bone marrow or solid organ transplants. Immunodeficient patients with mutations in specific genes, can develop lymphoproliferation associated with EBV or EBV-positive B cell lymphomas. EBV is associated with some diseases in which the virus persists in T cells or NK cells. One of these diseases has been referred to as hydroa vacciniforme-like lymphoproliferative disorder. The classic form of this disease is indolent, self-limited, and more common in whites. The systemic form is severe and includes fever, lymphadenopathy, and often liver involvement, and it is more common in Asians and Latin Americans. In 2023, after consultation with several pathologists, based on clinical studies by our group and others, this disease has been renamed hydroa vacciniforme lymphoproliferative disorder by an International Consensus Clinical Advisory Committee since it is known now that all lesions from these patients contain EBV. EBV has also been associated with chronic active Epstein-Barr virus infection in which the virus infects B, T, or NK cells. After extensive discussions with pathologists, based on our clinical studies and those of others and because most adults are chronically infected with EBV, this disease has now been renamed chronic active Epstein-Barr virus (CAEBV) disease. Previously, CAEBV disease included patients with EBV-infected T, NK, or B cells; however, we have found that many patients that had been diagnosed with B cell CAEBV have underlying primary immunodeficiencies; therefore, patients with EBV in B cells are no longer classified as having chronic active EBV disease.

View original record on NIH RePORTER →