Animal Models of Emerging Viral Infection

Clinical Center

Investigators

Linked publications, trials & patents

Abstract

Project 1: We previously developed a NHP ICU model in healthy (uninfected) NHPs. We have extended this model to included supportive care of animals infected with E.coli or K. pneumoniae. Among K. pneumoniae infected animals, we have completed initial bacterial dose-response studies and are now proceeding with our first intervention trial with a host-targeted potential therapy. Additionally, we have completed a 2-animal pilot study providing supportive critical care to NHPs infected with Ebola virus. This study was successfully implemented in the NIAID biosafety-level (BSL)-4 Integrated Research Facility (IRF) in Fredrick, MD and will subsequently be implemented in NIAID BSL-4 Rocky Mountain Laboratories in Hamilton, Montana.