Identifying small molecules with selective toxicity towards muscle invasive prostate cancer cells

National Center For Advancing Translational Sciences

Investigators

Abstract

This project team aims to screen and develop chemical probes with differential drug sensitivity profiles of a muscle-invasive prostate cancer cell line. During this period, more than 10,000 compounds from oncology-focused and clinically-approved libraries were screened using cell viability assays to identify chemical probes that lethally and specifically target muscle-invasive prostate cancer cell lines, relative to parental and diverse prostate cancer cell models. Several classes of compounds with distinct mechanisms of action were identified and selected for follow-up studies.