Identifying novel antibiotics by targeting the EF-Tu complex formation

National Center For Advancing Translational Sciences

Investigators

Abstract

During this reporting period, the collaborative team performed screening of approximately 20,000 compounds towards identifying small molecules that inhibit the interaction between EF-Tu and tRNA. Follow-up studies are underway to further characterize hits and identify compounds that show on-target bactericidal activity. Additionally, pharmacokinetic and in vivo studies have been performed using a molecule identified in an earlier round of screening. Topical formulations of this compound are being studied for the treatment of skin infections.