Howard University Research Center for Minority Health and Health Disparities

$220,850U54FY2023MDNIH

Howard University, Washington DC

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Abstract

There are mounÆng evidence showing children exposed to HIV but uninfected (HEU) during pregnancy as the pregnant mother is on chronic cART present with higher cardiovascular risk at birth and beyond. In order to miÆgate these risks, there is an urgent need to understand the effects of the daily intake of the recommended HIV treatment, combined anÆretroviral therapy (cART), on the newborn during pregnancy. It is important to isolate the cardiac side effects of the cART in HEU from any residual maternal viral load effects. Therefore, we will study the effects the components of the cART given to non-infected pregnant rodent model on the HEU. Furthermore, an assessment of the breastieeding potenÆal compounding effect will be performed on breastied rodents. This study is of high relevance to the communiÆes with high HIV risk and cardiovascular diseases, such as in underserved populaÆon afflicted with health dispariÆes. Understanding the cause can help future studies to alleviate the symptoms.

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