Dissecting the influence of DNA damage response and homologous recombination deficiencies on tumor immunogenicity

Icahn School Of Medicine At Mount Sinai, New York NY

Investigators

Linked publications & trials

Abstract

PROJECT SUMMARY This Diversity Supplement will support the career development of Ezekiel Olumuyide who will perform PhD thesis studies under the mentorship of Robert Samstein. The parent grant (DP5 grant OD028171, “Dissecting the influence of DNA damage response and homologous recombination deficiencies on tumor immunogenicity”) will examine the immunogenicity of DNA repair defects on the innate and adaptive immune responses. In this supplement proposal, Ms. Olumuyide will utilize a novel protein-barcoded CRISPR screen technology to assess a wide panel of genes. The candidate career development plan will include intensive training in oral and written communication, grant writing, technical skill development with experimental mouse modeling and immunophenotyping, and didactic training in computational immunology.