Open-source Software Development Supplement for 3D quantitative analysisof mouse models of structural birth defects through computational anatomy

Seattle Children'S Hospital, Seattle WA

Investigators

Linked publications & trials

Abstract

The primary goal of this supplement is to develop user-friendly, UI driven modules as part of the open-source 3D biomedical imaging suite 3D Slicer to facilitate easier discovery of novel phenotypes in quantitative screens of model organisms that have been experimentally manipulated. We will convert our analytical pipelines based on deformable image registration and deep-learning methods, which are developed for our parent grant, into re- usable, general-purpose modules. The end-users of these tools need minimal experience with specifics of biomedical image analysis and/or computer vision concepts, thereby will be able to apply the tools directly to their specific question.