Dissecting the central and peripheral mechanisms to fentanyl induced respiratory depression

Washington University, Saint Louis MO

Investigators

Abstract

In this application we propose studies to assess how fentanyl complicates treatment of opioid overdose. In addition, our proposed studies might establish the mechanisms underlying fentanyl-induced respiratory depression. Overall, findings generated in this proposal will eventually lead to develop new therapeutic interventions to prevent and rescue fentanyl-induced fatal overdoses.