The relationship between fMRI and patient-reported outcomes in chemotherapy-induced neuropathy:  A diversity supplement

University Of Texas Hlth Sci Ctr Houston, Houston TX

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Abstract

Summary of Parent Grant (R01CA245054) Chemotherapy induced neuropathy (CIN) is a severe side effect that impacts greater than 60% of cancer patients. CIN impacts treatment duration and dosing, functional mobility, and quality of life. This proposal examines the effect of auricular point acupressure (APA) as an innovated solution for CIN. APA utilizes a non-invasive, active modality of treatment stimulating points on ear to improve CIN symptoms. Utilizing a mobile application on smartphones, this project teaches participants how to stimulate their ears for three minutes, 3 times a day to alleviate pain. Given limited understanding of the mechanism of pain relief, participants will complete multiple questionnaires: Quantitative Sensory Test, Revised Brief Pain Inventory-CIN, PROMIS- 29, Opioid Use, Experience and Attitude, and Demographic data. Additionally, imaging studies and biomarkers will be obtained. Functional MRI (fMRIs) will obtain pre-, post-, and follow-up APA evoked signal changes and pro- and anti- inflammatory cytokines will be collected. The goal of this study is to ascertain the efficacy of APA as a self-managed, adjunctive therapy to enhance CIN management, through understanding the underlying mechanisms of APA on CIN.