Supplement: Recombinant microRNAs in xenobiotic metabolism and disposition

$60,000R35FY2023GMNIH

University Of California At Davis, Davis CA

Investigators

Linked publications & trials

Paper 39585047 Paper 39345479 Paper 39345391 Paper 39114355 Paper 38733599 Paper 38719476 Paper 38429100 Paper 38177179 Paper 37799388 Paper 37170982 Paper 36948592 Paper 35755805 Paper 35732999 Paper 35680378 Paper 35579419 Paper 35556790 Paper 33754032 Paper 33359565

Abstract

PROJECT SUMMARY This Administrative Supplement to ongoing R35GM140835 award is to seek for purchasing a new liquid chromatograph (LC) system that will be used to determine the purity of novel recombinant microRNAs (BioRNAs) generated through in vivo fermentation production and accurately quantitate target xenobiotic/drugs and metabolites in complex biological samples. These studies are critical elements in the MIRA award which will establish the role and importance of microRNAs in posttranscriptional regulation of xenobiotic metabolism and disposition.

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