Role of KCNQ2 Channels in Control of Breathing

University Of Connecticut Storrs, Storrs-Mansfield CT

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Abstract

SUMMARY DevelopmaenndetpaillepntciecphalaospsaotchiwyaittKehCdNQc2hannhealsbseepnrimalriinlktyeod loss-of-KfCuNnQcm2tuitoantiHoonwse.vaenri,ncreansuimnbgoefrrecurKrCeNnQtg2ain-of-fun vari(ain.tRes2.0C,1)havbeeeindentPiaftiiewedin.thshKeCNQR221oc mutatdiiosnpsleavyemryeoclonu andearplryofohuynpdoventdiuletaorteidounccehdemoreCfulrerxe.mnetclhya,nibsywmhsicKhCNQ2 channceolnsttrhdoerlitvobereaatrhueencleTahrer.etrotrnaupcelz(eoRuiTsdiNsa)nimporrteasnptirat centneeru;rointshriesgifounncatsiroenspircahteomroyrecbeyprteogruslatinginrespotnose breathin changientsisCsOu2.eChemosenRsTiNnteiuvreaornaesctivbayatniendcreianCsO2/eH+,whereagaasin­ of-funKctniqmo2untatmiioghnhytperpoRlTaNnreiuzreaonmdsakiemtordeiffitcoruelstptoonCdO2/H+. Indeweodr,fkrotmhpearegnrtasnhtowtehdeaxtpresosftihroeencurKrcennqmt2utatKiconnRq221ocinRTN neurbolnusntthevedentirleastpoortnyoCsOe2.Excitwienagllsfyoo,utnhdaKtcnqc2hanancetliivnRiTtNy neuroinsrsegulbaytaed+-Hmyo-Incoos!irtaonls(pHoMrItwTeh)ricihmpomrytos-intososiutpoplort producotfpihoonsphatid4y,l5i-nboissipth(ooPls2I)pP,ahnaatlelosatcetriivocafKtconrqc2hannHeMlIsT. expresisntihoRenTNregiiosrnestroinclttyoecdhemosennseiutrioTvnhese.refwoehryep,othtehsaitze HMIiTsrequfiorKrecdnqc2hanancetliivnRiTtNnyeuroInnpsa.rtiwceuplraorp,tohsHae+t-depenmdyeon­t inostirtaonlsipnotRroTtNneurobnyHsMIwTiilnlcrePaI2sPleevaenldsactiKvcantqec2hannteollismit CO2/H+-stimualcattiaevdsiwteyla,lstomaintnaeiunrmaoldulabtynieounrotrantshmasititgttneharrlsough Gq-courpelceedpatnodPrIs2PhydrolTyhsutishs,oe.bjecotftihvaiepspliciasttodieotnertmhieenxetetnot whiKcchnqc2hannaenlHdsMIiTntetrocaocnttRrToNclhemorecuenpdtneiorornmcaolndiatniwdohnesther HMIcTabnetargettoiemdprborveatihnmiincgtehaetxprKecsnsRq22o1.cThethrSepeecAiifmioscfthis projaerce1t:)detertmhieenxetetnowthiHcMhIiTnfluKecnncqec2shanrnegluloaftcihoenmosensit RTNneuro2n)dse;tercmoinnteriboufKtcinoqcn2hsannaenldHsMIiTnteratcoRtTiNocnhsemorecep netweoxrckitaabnid3l)tioetsyt;abHlMiIsiThnRTNneuroansastherapteaurtfgioeKcrtcnqa2ssociat breatahbinnogrmaTlhiertaiteisof.notarhlrieesseairstchhabtyundersthaonwHdMiInrTgegulKactneqs2 chanancetliivnRiTtNyneurownecsa,lnaayfoundaftodireovnelotprienagtmfeornretsspirpartoobrlyems associwaitKehcdnqm2utations.