Proteogenomic Characterization of Tumor Tissues and Preclinical Models with High Precision

Johns Hopkins University, Baltimore MD

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Abstract

Summary During the last 12 years of since CPTAC2, the JHU Proteome Characterization Center (JHU/PCC) has repeatedly demonstrated superior technological innovation and robust data generation that have played critical roles in the success of CPTAC's core mission of accelerating the understanding of the molecular basis of cancer through the application of large-scale proteome analysis technologies to different cancer types. For this project, we aim to generate accurate, reproducible, sensitive, quantitative, and multiplexed proteomic analysis using optimized and standardized high- throughput technologies. We will leverage our established Center infrastructure and capitalize on our success in clinical cancer proteogenomic discoveries to characterize proteins and protein phosphorylation from The Children's Hospital of Philadelphia, on behalf of itself and the Children Brain Tumor Tissue Consortium (CBTTC), the Children's Brain Tumor Network, a part of the Center for Data Driven Discovery in Biomedicine at CHOP ) (CBTN). We will identify unique features that are inherent to proteins such as phosphorylation that have been included in our current PCC. Understanding the molecular network in carcinogenesis is essential for the advancement of precision cancer medicine and development of a successful strategy to reduce cancer mortality.