PAROXETINE--TREATMENT OF EXAGGERATED PLATELET REACTIVITY WITH MAJOR DEPRESSION

$293,069M01FY2002RRNIH

Emory University, Atlanta GA

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Abstract

This study is an amendment to SPID 3251 to add two weeks of open-label combined treatment with paroxetine, aspirin and clopidogrel to further elucidate the mechanism whereby the antidepressant, paroxetine, diminishes activation of the GPIIb/IIIa receptor in patients with major depression.

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