STAT-1 IN AIRWAY INFLAMMATION AND BRONCHIAL HYPERREACTIVITY IN ASTHMA

$0M01FY2002RRNIH

Washington University, Saint Louis MO

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Abstract

Airway epithelial cells are known to play a key role in orchestrating specific inflammatory immune responses important in the pathogenesis of asthma. This research proposal seeks to define the role of a signal transduction protein, STAT-1, in promoting immune cell influx and retention in the airway and how this disturbance of the airway epithelial cells may be curcial to the perpetuation of bronchial hyper- reactivity in the chronic asthmatic process.

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