BMS191352 IN ADVANCED CARCINOMA

$0M01FY2002RRNIH

University Of Alabama At Birmingham, Birmingham AL

Investigators

Linked publications & trials

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Abstract

This is a phase I trial of the toxin immunoconjugate BR96 sFv-PE40 which consists of a single chain antibody targeting the Lewis(y) antigen linked to the cytoxic moiety of Pseudomonas exotoxin. The phase I trial has demonstrated the feasibility of demonstration of this immnotoxin to patients, and in the first two dose levels has demonstrated no dose- limiting toxicity. The immunoconjugate is immunogenic, and elicits a prompt immune response to the Pseudomonas exotoxin component, but impact of this immune response on kinetics has yet to be determined.

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