The genetic basis for age-related hearing loss in outbred mice

University Of California, San Diego, La Jolla CA

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Abstract

Summary Age-related hearing loss (ARHL) has been linked to age-related cognitive decline. To date, no studies have looked in detail at these two processes in a preclinical animal model. In this proposal we will, for the first time, characterize the age-related changes in neural connectivity within the inner ear and brain in a premature aging mouse model and explore the potential for two small molecules to prevent/regenerate these lost synapses.