Mechanisms of T cell activation in cardiac fibrosis and non-ischemic heart failure

Tufts University Boston, Boston MA

Investigators

Linked publications, trials & patents

Abstract

While great strides have been made to diversify the health sciences professions, there are still a disproportionately low number of individuals from underserved groups entering the biomedical sciences. This research supplement is submitted with the strong conviction that by offering advanced education and training opportunities in a thriving biomedical research environment, we can increase the participation of individuals currently underrepresented in the biomedical sciences. The proposed research plan and strategy build up on findings from the parent R01 HL144477 that expand to new studies not proposed in the parent grant, which have never been reviewed or deleted by the initial review group and are a logical extension to discover new mechanisms of cardiac T cell mediated inflammation and fibrosis in non-ischemic heart failure, which will result in an integral part of the parent R01. The present research plan and strategy will be a central component of an enriching diversity supplement experience for Maria Zambrano, a motivated graduate student who will perform all the proposed studies to test new hypotheses in the field of cardiac fibrosis (CF) and T cell inflammation. Maria will use tools developed in the parent grant and in vitro and in vivo experimental approaches to investigate the role of cardiac- fibroblast crosstalk in chemotherapy induced cardiomyopathy,