A 400 MHz NMR Spectrometer

Brandeis University, Waltham MA

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Abstract

Project Summary We are requesting funds to purchase a new Bruker Avance Neo 400 MHz spectrometer with multinuclear capability. This instrument is intended to replace our two current general use 400 MHz spectrometers that are both aging and difficult/expensive to keep running, both being Varian/Agilent instruments that are no longer supported. The Bruker Neo 400 will be used for walk-up 1D 1H NMR, as well as 13C, 31P, 19F, 11B spectra, variable temperature and 2D experiments. Currently, walk-up 400 MHz NMR is required for the research of 10 Brandeis PIs in Chemistry, Biochemistry and Biology, comprising 6 Major and 4 Minor users who are supported by eight R01 or R35 (MIRA) grants, two R21s and an R03, three NSF grants, one Air Force grant and HHMI Investigator funding. A new, manufacturer-supported 400 MHz spectrometer is crucial to ensuring the continued research progress of our NIH-funded chemists, biochemists and biologists for the next decade.