Role of histone variants in aging and cancer

Division Of Basic Sciences - Nci

Investigators

Linked publications, trials & patents

Abstract

We are currently focused on analysis of chromosome translocations and mechanisms involved in the breaks and repair machinery involved in the translocations. Using high resolution microscopy coupled to machine learning, we are currently finding new ways to automatically score patient samples for translocations involving the CENP-A domain we mapped in previous publications, and using small molecule inhibitors that can disrupt these pathways. These translocations and amplifications occur in virtually every time of solid tumor we have examined. We have expanded our work significantly to include adult glioblastomas and aging tissues derived from human patients. In collaboration with NIA, we also contributed to a study examining chromatin dynamics in aging mice.