Myeloid TGFbeta signaling in breast cancer metastasis

Division Of Basic Sciences - Nci

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Abstract

We have made steady progress in the past years. We have produced and bred mouse colonies in which TGFbeta R2 receptor is specifically deleted in myeloid cells. We have observed significantly decreased tumor progression in myeloid TGFbeta R2 ko mice. We obtained mechanistic insight that involves systemic immune response as well as altered local immune microenvironment. We have identified that miRNA130a and miRNA145 directly target myeloid TGFbeta R2 and its associated signaling networks the IGFR pathway. We hope to develop new translational opportunities with the research information obtained. We are utilizing technical core resources and collaborating with several labs for this project.