Translational Studied of Chondroitin Sulfate Proteoglycans

National Heart, Lung, And Blood Institute

Investigators

Linked publications, trials & patents

Abstract

The objective of this project is to develop potential approaches to the therapy of brain and spinal cord injury. One approach is to limit the production or increase the degradation of chondroitin sulfate proteoglycans (CSPGs). We have found that xylosides, compounds that are used to alter proteoglycan GAG chain composition, have significant actions at concentrations lower than those previously reported to reduce GAG chains can alter growth cone morphology. Evidence points to a novel signaling mechanism triggered by xylosides only at low concentrations. These results have been published.