Characterization/Inhibition of Tyr-DNA Phosphodiesterase

San Diego State University, San Diego CA

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Abstract

DESCRIPTION (provided by applicant): Tyrosyl-DNA phosphodiesterase I hydrolyzes Topoisomerase Ib from substrate DNA. Tyrosyl-DNA Phosphodiesterase appears to be involved in replication-induces double strand DNA breaks and an attractive chemotherapeutic target. This project aims to characterize this enzyme and discover an inhibitory molecule by deconvoluting combinatorial libraries.