Association Study of Orofacial Cleft Risk Variants across All of Us Cancer Diagnoses

University Of Pittsburgh At Pittsburgh, Pittsburgh PA

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Abstract

ABSTRACT This new grant is a Revision/Administrative Supplement to parent grant R03-DE032062. It has long been noted that individuals with orofacial clefts (OFCs) and their unaffected relatives have a higher risk of certain cancers. The hypothesis of this revision is that the association between OFC and cancer is in part due to genetic commonalities. In this Revision, we will investigate possible associations between OFC genetic risk variants with the cancer diagnoses in All of Us.