2. Optical Coherence Elastography of the Cornea

$55,386R01FY2022EYNIH

University Of Houston, Houston TX

Investigators

Kirill V Larincontact Salavat R Aglyamov Michael D Twa

Linked publications & trials

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Abstract

PROJECT SUMMARY This project will require me to develop and build an ultrafast compressional OCE system for high resolution mapping of corneal biomechanical properties in 3D. This system is based on an ultra-fast Fourier Domain Mode Locked swept source laser. Following data acquisition, I will also be implementing signal processing algorithms that will isolate the actuator-induced displacements in the cornea. The system will be validated with a series of tissue-mimicking phantoms, followed by ex vivo samples. To assess the capability of the system to measure changes in corneal biomechanical properties, various crosslinking (CXL) treatments will be applied to the ex vivo corneas, including traditional and custom CXL treatments. These measurements will enable me to optimize the imaging parameters and signal processing algorithms. After validation, in vivo volumetric OCE measurements will be performed in various rabbit models. Similar to the ex vivo samples, both traditional and custom CXL therapies will be applied in order to assess the efficacy of the system to map changes in corneal biomechanical properties. Custom CXL shows great promise for improving CXL outcomes by limiting the area of treatment to only the weakened tissue but is currently only guided by corneal topography. Additionally, with 3D OCE, biomechanically-guided custom CXL could potentially and drastically improve CXL outcomes with personalized therapies.

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