Glucose Transporter Regulation in Obesity and Diabetes

Beth Israel Deaconess Medical Center, Boston MA

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Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Bridge Funding for DK43051– PI: Barbara B. Kahn, MD Long-term Overall Goal: To determine the mechanisms by which reduction of ChREBP in adipocytes causes systemic insulin resistance and impaired glucose transport in adipocytes. Background: Carbohydrate Response Element Binding Protein (ChREBP) is the major transcription factor regulating de novo lipogenesis (DNL, fatty acid synthesis from glucose) in adipocytes. We showed that adipose-selective ChREBP KO (AdChREBP KO) causes systemic insulin resistance and impairs insulin-stimulated glucose transport in adipocytes. In humans, expression of ChREBP and genes regulating DNL in adipose tissue correlate highly with insulin sensitivity measured by clamp. Specific Aims for One Year: Specific Aim 1: To maintain lab staff Specific Aim 2: To maintain mouse lines Specific Aim 3: To generate additional preliminary data