Genetic analysis of NIDDM in Finnish population
$0Z01FY2001HGNIH
Human Genome Research
Investigators
Linked publications & trials
Paper 36224396Paper 29481666Paper 27618452Paper 27618447Paper 26637976Paper 26551672Paper 25187374Paper 24879641Paper 24586696Paper 24584071Paper 24296717Paper 23835345Paper 23754948Paper 23557707Paper 23555291Paper 22885924Paper 22885922Paper 22182842Paper 22082242Paper 21421807Paper 21035756Paper 20935630Paper 20935629Paper 20881960Paper 20686565Paper 20581827Paper 20299549Paper 19933169Paper 19557161Paper 19502414Paper 19430483Paper 19079261Paper 19060908Paper 19060907Paper 19060906Paper 18521185Paper 18451988Paper 18372903Paper 18193045Paper 17463248Paper 17192490Paper 17179727Paper 16936217Paper 16936201Paper 16374835Paper 16142453Paper 16039295Paper 15936967Paper 15652721Paper 15517149Paper 15047633Paper 14988271Paper 14988269Paper 13677425Paper 12502516Paper 12482934
Abstract
We have collected DNA and extensive phenotypic information on families with type 2 diabetes mellitus in Finland. Full genome scanning has identified regions of chromosomes 20, 22, 11, X, 6, and 3 that appear to harbor susceptibility genes. Fine mapping with closely spaced SNP markers is underway on chromosomes 20 and 22 to seek evidence for association. For that purpose, we have established the technique of MALDI-TOF mass spectrometry for SNP genotyping, and successfully demonstrated its application to DNA pools. Using this methodology, we have also confirmed an association of the Pro12Ala variant of the PPARG gene with type 2 diabetes, and are investigating a number of other candidate genes.
View original record on NIH RePORTER →