Identification Of Genes Causing Hearing Impairment

$0Z01FY2001DCNIH

Deafness &Other Communication Disorders

Investigators

Linked publications & trials

Paper 26544806 Paper 26469390 Paper 26321635 Paper 26302205 Paper 26301261 Paper 25960948 Paper 25941349 Paper 25898120 Paper 25758223 Paper 25491636 Paper 25425308 Paper 24561068 Paper 24387994 Paper 23979167 Paper 23770805 Paper 23541340 Paper 23235333 Paper 22718019 Paper 22211675 Paper 22200607 Paper 22116369 Paper 21965328 Paper 21255762 Paper 20170899 Paper 19998422 Paper 19756182 Paper 19650862 Paper 19645628 Paper 19603065 Paper 19578036 Paper 19576567 Paper 19287372 Paper 19057657 Paper 18719945 Paper 18663477 Paper 18505454 Paper 18279434 Paper 18181211 Paper 18179891 Paper 18028453 Paper 17690910 Paper 17653769 Paper 17546645 Paper 17331196 Paper 17250663 Paper 17186462 Paper 17066295 Paper 17049805 Paper 16973713 Paper 16807332 Paper 16799054 Paper 16459341 Paper 16385457 Paper 16374329 Paper 16158433 Paper 15882574 Paper 15829536 Paper 15711797 Paper 15654330 Paper 15538632 Paper 15447792 Paper 15354000 Paper 15286153 Paper 15254021 Paper 15211351 Paper 15060111 Paper 15028842 Paper 14604828 Paper 14604820 Paper 14570705 Paper 14569126 Paper 14527306 Paper 13680526 Paper 12923420 Paper 12913076 Paper 12865764 Paper 12865758 Paper 12746400 Paper 12711741 Paper 12687499 Paper 12408088 Paper 12408079 Paper 12408077 Paper 12393799 Paper 12145746 Paper 12107438 Paper 12075507 Paper 11964073 Paper 11863357 Paper 11850623 Paper 11850618 Paper 11784272 Paper 11735029 Paper 11583965 Paper 11527035 Paper 11424922 Paper 11398101 Paper 11163249 Paper 11101839 Paper 11090341

Abstract

The goal of this project is to map and identify genes for herditary deafness. Linkage analyses are being conducted in several large pedigrees segregating non-syndromic and syndromic forms of deafness. If linkage to the known syndromic, DFNA (dominant) and DFNB (recessive) loci in large families are excluded, we initiate genome-wide screens. This strategy has allowed us to map new deafness loci such as DFNA20, DFNA27, DFNA28 and DFNA36. The chromosomal map locations of these novel deafness genes are then refined prior to initiating positional cloning strategies to identify the genes responsible for the hearing loss. Recently we have identified genes for DFNB12, DFNA28 and Usher 1D. Additional families with dominant and recessive modes of inheritance with profound congenital or progressive hearing loss are being ascertained with the goal of mapping and cloning additional novel genes that are necessary for hearing and/or maintenace of the auditory system. We are also asscertaining families, mapping loci and identifying genes for Usher syndrome. The defining clinical features of Usher syndrome are hearing loss and progressive retinopathy.

View original record on NIH RePORTER →