NME Mouse Core

$192,369P01FY2022AINIH

University Of Minnesota, Minneapolis MN

Investigators

Linked publications & trials

Paper 39008691 Paper 37862030 Paper 37738858 Paper 37561596 Paper 36921574 Paper 36865264 Paper 36802427 Paper 36374464 Paper 36316474 Paper 35794484 Paper 34824268 Paper 33956235 Paper 33929324 Paper 32895539 Paper 32737148 Paper 32687575 Paper 31451631 Paper 31324724 Paper 31205227 Paper 31034767 Paper 31025378 Paper 31010850 Paper 30865878 Paper 30858199 Paper 30643267 Paper 30613389 Paper 30516351 Paper 29844327 Paper 29644257 Paper 29436413 Paper 29259578 Paper 29255075 Paper 28842400 Paper 28800929 Paper 28709804 Paper 28539428 Paper 28530714 Paper 28320913 Paper 27986907 Paper 27802388 Paper 27656680 Paper 27588199 Paper 27292946 Paper 27096360 Paper 27092794 Paper 27043411 Paper 26829766 Paper 26823430 Paper 26726812 Paper 26693713 Paper 26624012 Paper 26424648 Paper 26378075 Paper 25774295 Paper 25769925 Paper 25727290 Paper 25636798 Paper 25601203 Paper 25137456 Paper 24943217 Paper 24830344 Paper 24592261 Paper 24465555 Paper 24123682 Paper 23804712 Paper 23663778 Paper 23487759 Paper 23100562 Paper 23071255 Paper 22706089 Paper 22124124 Paper 21873213 Paper 20861357 Paper 20855870 Paper 20601952 Paper 20363604 Paper 20016506 Paper 19935657 Paper 19843938 Paper 19592655 Paper 19342641 Paper 19200757 Paper 18832689 Paper 18354196 Paper 18250416 Paper 18097015 Paper 18086865 Paper 17656106 Paper 17545279 Paper 17484770 Paper 17383196 Paper 17382557 Paper 16703564 Paper 16686755 Paper 16670295 Paper 16585558 Paper 16277698 Paper 16177080 Paper 15814665 Paper 15634875

Abstract

Summary Core B NME Mouse Core Our published studies suggest that mice with more physiological exposure to natural mouse microbes have immune systems that are a better match for the immune system in humans: In contrast to typical âcleanâ laboratory mice (which are maintained in barrier facilities to avoid pathogen exposure) these âdirtyâ mice â also called normal microbial experience (NME) mice â may therefore be more useful to model the characteristics and function of the human immune system, including the maintenance and breakdown of immune tolerance. The goal of this NME Mouse Core is to reliably and cost-effectively produce NME animals that can be used by the Projects in this P01, including careful quality control of these animals to make sure that they are suitably well defined for interpretable studies.

View original record on NIH RePORTER →