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Gene Delivery and Addiction

$177,035ZIAFY2021DANIH

National Institute On Drug Abuse

Investigators

Brandon Harveycontact

Linked publications & trials

Paper 35981704Paper 35216090Paper 34083381Paper 31396586Paper 31242442Paper 31069753Paper 30622165Paper 29766045Paper 29453460Paper 29397902Paper 28774929Paper 28690111Paper 28596111Paper 28403212Paper 28380331Paper 28260198Paper 27534267Paper 27189755Paper 26985037Paper 26554386Paper 26019014Paper 25640183Paper 25377775Paper 25242321Paper 25220237Paper 23817545Paper 23736082Paper 23283335Paper 23211962Paper 21411666Paper 21349337Paper 21182575Paper 20950593Paper 20053904Paper 20018732Paper 19620976Paper 19442829Paper 19345340Paper 18803283Paper 18642641Paper 18598737Paper 18082966

Abstract

In collaboration with Dr. Peter Kalivas (MUSC), we employed our D1-Cre and D2-Cre rats to study the role of Focal adhesion kinase and cofilin in dopamine D1 receptor-expressing and dopamine receptor D2-expressing neurons in relapse-associated transient synaptic potentiation. Here we provided additional characterization data of the D1-Cre and D2-Cre rats produced as part of the Transgenic Rat Project at the NIDA Intramural Research Program. This work has been published in the Journal of Neuroscience. In collaboration with Dr. Carl Lupica (NIDA IRP) and Dr. Bruce Hope (NIDA IRP), we developed and characterized a Parvalbumin-Cre driver rat and used it to examine serotonin signaling in the rat orbitorfrontal cortex parvalbumin neurons in response to cocaine withdrawl. This work has been published in eNeuro.

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