Cancer Stem Cells in Cholangiocarcinoma
$711,015ZIAFY2021CANIH
Division Of Basic Sciences - Nci
Investigators
Linked publications, trials & patents
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Abstract
This project will use cutting-edge technology to dissect the interaction between cancer stem cells of cholangiocarcinoma with immune cells in tumor microenvironment. We will: 1. Use human cholangiocarcinoma cell lines to study the YAP1 signaling pathway in cancer stem cells; 2. Use an animal model of cholangiocarcinoma to trace the role of cancer stem cells during tumorigenesis; 3. Use spatial transcriptomics technology to study the interaction between human cholangiocarcinoma cancer stem cells and neighboring immune cells in tumor microenvironment. This work began in July 2019.
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