Development and validation of a predictor of meningioma recurrence

Division Of Basic Sciences - Nci

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Abstract

An important clinical problem in the management of patients with meningiomas is the difficulty in predicting recurrence at the individual patient level, limiting appropriate selection of patients who would benefit from adjuvant therapy to delay recurrence. Grading of tumors is based entirely on histology, without molecular considerations, but recent data suggest the utility of DNA methylation profile as a clinically relevant biomarker. We therefore aimed to develop and validate a combined molecular and clinical predictor of meningioma recurrence in individual patients to help personalize decision making regarding adjuvant treatment. Results indicate that a molecular definition of meningioma may yield clinically relevant subtypes that can be used to optimize therapeutic decisions.