Effects of systemic and topical perturbations on human microbes

Division Of Basic Sciences - Nci

Investigators

Linked publications & trials

Abstract

The goal of this project is to implement systematically different skin-directed and systemic modalities in healthy volunteers and patients to explore how human microbial communities are altered. In addition to identifying changes in host microbial communities, we have been working to develop ways to study the potential effects of microbiome alterations on host health and disease. In the last fiscal year, we have continued to study samples from patients with specific disorders and healthy volunteers for possible microbiome changes related to interventions. Additionally, we are working with collaborators who have interventional protocols to investigate the composition of host microbial communities prior to and after implementation of systemic or topical interventions. These include studies of immunotherapy treatments in oncology patients and antimicrobials in human subjects.