T Cell Regulatory and Suppression Mechanisms in Malaria

National Institute Of Allergy And Infectious Diseases

Investigators

Linked publications, trials & patents

Abstract

We highlight here the results from our studies published in FY2020: 1. Attaher O, Zaidi I, Kwan JL, Issiaka D, Samassekou MB, Cisse KB, Coulibaly B, Keita S, Sissoko S, Traore T, Diarra K, Diarra BS, Dembele A, Kanoute MB, Mahamar A, Barry A, Fried M, Dicko A, Duffy PE. Effect of Seasonal malaria chemoprevention on immune markers of exhaustion and regulation. Journal of Infectious Diseases. 2020 Jan 1;221(1):138-145. doi: 10.1093/infdis/jiz415. Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Here, we used flow cytometry to explore the impact of seasonal malaria chemoprevention on malaria-induced immune dysfunction, as measured by markers associated with exhaustion and regulatory T cells. Children that received seasonal malaria chemoprevention had fewer malaria episodes and showed significantly lower fold changes in CD4+PD1+ and CD4+PD1+LAG3+ compared to those that did not receive SMC. Seasonal malaria chemoprevention had no observable effect on fold changes in CD8 T cells expressing PD1 or CD160. However, children receiving SMC showed greater increases in CD4+FOXP3+ T regulatory cells compared to children not receiving SMC. These results provide important insights into the dynamics of malaria-induced changes in the CD4 T-cell compartment of the immune system and suggest that the reduction of infections due to seasonal malaria chemoprevention may also prevent immune dysfunction.