Malaria Parasite Ligands And Host Cell Receptors

$895,579ZIAFY2021AINIH

National Institute Of Allergy And Infectious Diseases

Investigators

Linked publications & trials

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Abstract

Accomplishments during the year: 1. Develop an adjunctive therapy for children with cerebral malaria. This study has included the unique discovery of CD8 positive T cells in children who died of cerebral malaria. We are also working with DON available from NCI, the adjunctive therapy. We plan to obtain formulation and fill of the DON at the Univ. of Iowa. Dr. Doug Postels reeived a grant to fund the study in children with cerebral malaria. Reference:Riggle BA, Manglani M, Maric D, Johnson KR, Lee MH, Neto OLA, Taylor TE, Seydel KB, Nath A, Miller LH, McGavern DB, Pierce SK (2019). CD8+ T cells target cerebrovasculature in children with cerebral malaria. J Clin Invest 130, 1128-1138. https://doi.org/10.1172/JCI133474

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