Epidemiology and Genomics of Health Disparities

National Institute On Minority Health And Health Disparities

Investigators

Linked publications & trials

Abstract

For the Latina Breast Cancer Study, we collaborated with Drs. Neuhausen and Ziv to conduct whole genome sequencing (WES) of breast cancer tissue cases and controls from Latinas. Sample sequencing funded by NIMHD has been completed. This study identified common copy number amplified genes and commonly deleted genes. Further analyses are in progress to identify significant gene mutations from these samples and a manuscript is currently under preparation. In the Early Onset Colorectal Cancer Study among Puerto Ricans study, we collaborated with Drs. Cruz-Correa to conduct WES of colorectal cancer tissue cases and controls from Latinos. This study found that many mutations that were identified, were not located in exons. Variations in genomics regions that regulate gene expression may suggest to early-onset carcinogenesis. Another study among diverse breast cancer patients, demonstrated that regulatory networks that drive mammary luminal differentiation exhibit race-specific differences in their associations with clinical outcome. It suggests that the biomarkers and their downstream regulons will elucidate the intrinsic mechanisms that drive racial disparities in breast cancer survival. The PI will follow-up to ensure sequencing is uploaded to dbGaP as required by NIH. Dr. Jung Byun has left NIMHD DIR and we do not anticipate a renewal for this project.