Kinetic High Throughput Screening for Agonists and Inhibitors of the TRPML1 Ion channel

National Center For Advancing Translational Sciences

Investigators

Linked publications & trials

Abstract

During this period, ETB has worked to characterize and expand the most promising identified chemotypes through medicinal chemistry. As a center, ETB has fostered and maintained over 130 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to dozens of high-throughput screens and a number of medicinal chemistry campaigns to further improve on screening hits, providing our collaborators and the general research community with publications and a variety of promising small molecule probes and leads. In addition, ETB has worked to advance a number of informatic initiatives to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.