Cardiomyopathy Genomes Project

$37,741R01FY2021HLNIH

Northwestern University At Chicago, Evanston IL

Investigators

Elizabeth M McNallycontact Marcelo A. Nobrega

Linked publications & trials

Paper 39132495 Paper 38768074 Paper 38229148 Paper 38126226 Paper 38091294 Paper 37905408 Paper 37288552 Paper 37253881 Paper 37066275 Paper 36797366 Paper 36621880 Paper 36376295 Paper 36175057 Paper 35947370 Paper 35904451 Paper 35544088 Paper 35533732 Paper 35474678 Paper 35339388 Paper 35195661 Paper 34935411 Paper 34930020 Paper 34675193 Paper 34489471 Paper 34387095 Paper 34083488 Paper 34003581 Paper 33951936 Paper 33764162 Paper 33478249 Paper 33411631 Paper 33393498 Paper 32993371 Paper 32885733 Paper 32543992 Paper 32466880 Paper 32372669 Paper 32337338 Paper 32009526 Paper 31514952 Paper 30871346 Paper 30730308 Paper 30623133 Paper 30354430 Paper 29988018 Paper 29525646 Paper 29030407 Paper 28963182 Paper 28912180 Paper 28893959 Paper 28778945 Paper 28611034 Paper 28398466 Paper 27926775 Paper 27651888 Paper 27582060 Paper 27488191 Paper 26999602 Paper 26925501 Paper 26918958 Paper 26837737 Paper 26040335 Paper 25948554 Paper 25940966 Paper 25864169 Paper 24898741

Abstract

R01 HL128075 GRANT SUMMARY: As a leading cause of death, heart failure has become a pivotal focal point and increasingly recognized as being under genetic influence. Having a greater understanding of the mechanisms underlying heart failure and cardiomyopathy will improve application of current treatments and stimulate the development of new treatments. Through this work, we are interrogating both coding and noncoding regions for their role in the genesis and progression of heart failure. This diversity supplement is examining mechanisms of FLNC (filamin C) related cardiomyopathy since mutations in FLNC cause cardiomyopathy associated with arrhythmia burden.

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