An Integrative Science Approach to Resilience: The Notre Dame Study of Health & Well-being

University Of Notre Dame, Notre Dame IN

Investigators

Linked publications & trials

Abstract

Abstract ? UH3057039 The NDHWB provides a longitudinal research design and powerful analytic strategies that can help researchers understand the interrelated themes of stress exposure, appraisal, reactivity, resistance, and recovery, thereby informing the role of the physiological stress response in cognitive impairment, and ultimately Alzheimer?s disease and Related Dementias. What is needed to understand the precursors of Alzheimer?s disease is explicit data on genotypes associated with Alzheimer?s disease, structural images of the brain, levels of Amyloid-? and indicators of brain functioning (using TMS-EEG) during cognitive tasks. In confluence, the proposed research provides an unprecedented opportunity to study with multiple methods the stressors to which adults are exposed, the resistance resources upon which they draw, and the emotional and physiological processes through which stress is manifested and eventually contribute to physiological dysregulation, cognitive decline and the development of Alzheimer?s disease.