Functional neurovascular coupling in a mouse model of Alzheimer's Disease

State University New York Stony Brook, Stony Brook NY

Investigators

Linked publications, trials & patents

Abstract

Goal of Proposed Research Alzheimer?s disease (AD) is the most common neurodegenerative disease, presenting with progressive and irreversible memory loss and dementia. Although medications and management strategies can temporarily improve symptoms, no cure so far exists. Therefore, there is a high demand for underlying the cause, pathological conditions and behavioral symptoms of AD for advancing possible preventions and treatments. The central goal of the proposed research is to determine functional neurovascular coupling of the dentate gyrus and its underlying neural circuit mechanism in a mouse model of AD.