Shared Resources Core 1: Genomics/Epigenomics Core

$146,366P01FY2021CANIH

Rockefeller University, New York NY

Investigators

Linked publications & trials

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Abstract

PROJECT SUMMARY (MAJEWSKI) Mutations in histone and modifier genes in cancers have dramatic downstream effects on the landscape of the epigenome ? chromatin state and DNA methylation ? with eventual secondary outcomes manifested in gene expression and cellular phenotypes. Modern functional genomics approaches provide invaluable tools to study the effects of this epigenome-mediated cascade. In this Core activity, we will establish and provide a set of genomics tools and computation methods to elucidate the mechanisms through which histone variants impact the epigenome, transcriptome, and the cell identity during neoplastic transformation.

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