A Precision high content screening assay for AB-mediated neuronal cell cycle reentry

University Of Virginia, Charlottesville VA

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Abstract

Project Summary We have established a human iPS-derived neuronal-glial cell model system that we are using to (1) study A?O-induced neuronal cell cycle reentry (CCR) as well as (2) screen for compounds that inhibit A?O-induced neuronal CCR. We now propose to adapt this cell-based model system to evaluate the effects on SARS-CoV-2 spike protein-ACE2 binding on neuronal ?fitness?, responsiveness and intracellular signaling as well as use to screen for small molecule inhibitors that may used for the next generation SARS-CoV-2 therapeutics.